Antibody-Binding Proteins and Conjugates
Cayman Chemical 3-SIalylactosesodIum salt 50mg
An abundant oligosaccharide in the milk of many mammals, including cows and humans, particularly postpartum; avidly binds several viral strains, including strains of influenza, HIV-1, reovirus, and polyomavirus, in some cases altering viral infectivity
Cayman Chemical CeftIzoxImesodIum salt 50mg
A cephalosporin antibiotic; active against clinical isolates of the Gram-positive bacteria S. aureus, S. pyogenes, and S. epidermidis (IC50s = 1.56, ≤0.025, and 0.78 UG/ml, respectively), as well as clinical isolates of the Gram-negative bacteria E. coli, K. pneumoniae, and P. mirabilis (IC50s = 0.1, ≤0.025, and ≤0.025 UG/ml, respectively); protective against S. aureus, E. coli, P. mirabilis, or P. vulgaris infection in mice (ED50s = 4.03, 0.02, 0.255, and 0.038 mg/kg, respectively)
Cayman Chemical ParecoxIbsodIum salt 50mg
A prodrug form of valdecoxib; converted to valdecoxib by human liver microsomes in vitro and in vivo in rats, dogs, and cynomolgous monkeys; a CB1 agonist (EC50 = 2.4 µM in HEK293 cells); reduces hyperalgesia in a rat model of carrageenan-induced foot pad edema (ED50 = 5 mg/kg) and decreases inflammation in a rat model of M. butyricum-induced arthritis (ED50 = 0.08 mg/kg)
Revvity Health Sciences Inc AlphaScreen Anti-6His Donor Beads, 25 mg
AlphaScreen Anti-6His Donor Beads, 25 mg
Cayman Chemical SalcaprozatesodIum salt 500mg
An intestinal permeation enhancer; increases jejunal accumulation of the bioactive peptide PW5 in vitro in a non-everted rat gut sac model; increases plasma concentrations of orally administered human parathyroid hormone (1-34) in pigs
Cayman Chemical CntharIdIc AcIdodIum salt 50mg
A PP1 and PP2A inhibitor with IC50 values of 0.6 and 0.05 µM, respectively
Cayman Chemical RIsedronatesodIum salt 500mg
An aminobisphosphonate and antimalarial agent that inhibits bone resorption; inhibits growth of P. falciparum in vitro (IC50 = 20.3 µM) and P. berghei in vivo (25 mg/kg for one week); inhibits protein prenylation by preventing transfer of a farnesyl pyrophosphate group to parasite proteins
Cayman Chemical UDPD-GlucosesodIum salt 500mg
A nucleotide sugar and P2Y14 receptor agonist; induces inositol phosphate production in COS-7 cells expressing the human P2Y14 receptor (EC50 = 0.588 µM)
Biolegend TotalSeq™-C0961 PE Streptavidin
TotalSeq™-C0961 PE Streptavidin Reactivity: Human, Mouse, Rat, All Species; Apps: PG; Size: 10 ug
Jackson Immuno Research Labs Alexa Fluor 488-ChromPure Donkey IgG F(ab')2 fragment
Alexa Fluor 488-ChromPure Donkey IgG F(ab')2 fragment
MORADEC LLC Fab-αHFc-CL-DMDM, 50 μg, Human IgG Fc region specific, Cleavable linker, Alkylates DNA
Fab Anti-Human IgG Fc-Duocarmycin DM Antibody with Cleavable Linker is a specialized secondary antibody-drug conjugate designed for research applications. This product uniquely combines the Fab fragment of a polyclonal antibody with Duocarmycin DM, a cytotoxic small molecule, to facilitate targeted cell death through DNA alkylation. The cleavable linker ensures stability in extracellular environments and offers selective activation within cells for enhanced delivery of therapeutic agents. This approach creates opportunities for innovative antibody lead screening in ADC development.
- Target specificity for the human IgG Fc region
- Monovalent nature of the Fab fragment
- Stability in extracellular fluid
- Cleavable linker activated by intracellular cathepsins
- Alkylation mechanism targeting DNA minor groove
- Suitable for antibody pre-screening applications
- 50 μg quantity available